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- Bonomi et al (GOG 43) PMID 3894589
- Compared three regimens of cisplatin dosing
- Regimen 1: 50 mg/m2 every 21 days
- Regimen 2: 100 mg/m2 every 21 days
- Regimen 3: 20 mg/m2 for five consecutive days repeated every 21 days
- Differences in overall response rates were higher for regimen 2 (SS), but the PFS/OS/Complete response rates were virtually identical (NS)
- Established 50 mg/m2 as the preferred regimen due to lower toxicity and ease (regimen 3 had multiple hospital visits)
| Regimen
|
Number
|
PFS
|
OS
|
Response Rate (RR)
|
| 1
|
150
|
3.7
|
7.1
|
20.7%
|
| 2
|
166
|
4.6
|
7
|
31.4%
|
| 3
|
128
|
3.9
|
6.1
|
25 %
|
