Jump to content

Handbook of Genetic Counseling/Van Der Woude syndrome

Add links
From Wikibooks, open books for an open world

Van Der Woude syndrome

Eiology

[edit | edit source]
  • autosomal dominant
  • interstition deletion of IRF6 (interferon regulatory factor 6) on 1q32-41

Symptoms

[edit | edit source]
  • lower lip pit(s) (80%)
  • watery mucoid discharge, excessive salivation
  • hypodontia
  • absent incisors (central/lateral), canines, and/or bicuspids
  • cleft lip with/without cleft palate (with/without missing second premolars)
  • cleft uvula

Treatment

[edit | edit source]
  • surgical correction of the fistulas (accessory salivary glands)
Retrieved from "https://en.wikibooks.org/w/index.php?title=Handbook_of_Genetic_Counseling/Van_Der_Woude_syndrome&oldid=3307059"