Radiation Oncology/Breast/Male breast cancer
Breast Cancer in Men
Background
[edit | edit source]References: PMID 18042939
- Male breast cancer accounts for <1% of all breast cancer cases in the US.
- BRCA2:
- Overall, 14% risk of being BRCA2+ (unselected patients with male breast cancer)
- Risk of BRCA2+ in 77% in men with breast cancer in families with hereditary breast cancer
- Risk for development of breast cancer in BRCA2+ man: 6.3% by age 70 [1]; 2.8% by age 70 and 6.9% by 80[2]; relative risk of 102[3]
- BRCA1:
- Association is less clear than with BRCA2
Epidemiology
[edit | edit source]- MSKCC, 1999 (1973-94) PMID 10463981 -- "Localized male breast carcinoma and family history. An analysis of 142 patients." (Hill A, Cancer. 1999 Sep 1;86(5):821-5.)
- 142 pts treated at MSKCC or Ochsner Clinic.
- 5-year OS 86%, 10-yr 64%.
- 15% of pts had a 1st degree relative with breast cancer.
- Conclusion: Family history did not affect the age at diagnosis, duration of symptoms, the stage, or survival.
BRCA mutations
[edit | edit source]- NCI, 2007 PMID 18042939 -- "Breast cancer risk among male BRCA1 and BRCA2 mutation carriers." (Tai YC, J Natl Cancer Inst. 2007 Dec 5;99(23):1811-4.)
- Retrospective. 97 men with breast cancer identified in multicenter database of families with BRCA1 or BRCA2 mutations.
- Male BRCA1 carriers: cumulative risk of breast cancer by age 70 of 1.2%
- BRCA2: cumulative risk by age 70 of 6.8%
Retrospective series
[edit | edit source]- MSKCC,1999 - PMID 10463981
- see above under Epidemiology
- Princess Margaret, 1999 (1955-96) PMID 10091736 -- "Male breast carcinoma: a review of 229 patients who presented to the Princess Margaret Hospital during 40 years: 1955-1996." (Goss PE, Cancer. 1999 Feb 1;85(3):629-39.)
- Retrospective. 229 pts over a 42 yr period. 5-yr DFS 47%, OS 53%, LC 91%