Radiation Oncology/Cancer Syndromes/Cockayne Syndrome

Cockayne Syndrome

• wikipedia entry
• Emedicine entry
• DNA Repair chapter

• Mutations in ERCC6 and ERCC8, part of the NER pathway for single strand DNA damage repair
• Autosomal recessive syndrome
• Growth failure, impaired development of CNS, photosensitivity, premature aging
• No cancer predisposition