Radiation Oncology/Cervix/RTOG Cervix

• RTOG Website
• Wikibooks list of RTOG trials

CERVICAL CANCER: RTOG OPEN TRIALS

Number	Title
07-24	Phase III Randomized Study of Concurrent Chemotherapy and Pelvic Radiation Therapy with or without Adjuvant Chemotherapy in High-Risk Patients with Early-Stage Cervical Carcinoma Following Radical Hysterectomy

CERVICAL CANCER: RTOG CLOSED TRIALS

Number	Title	Publication PMID XXXXXXXXXX
04-18 Clinicaltrials.gov	A Phase II Study of Intensity Modulated Radiation Therapy (IMRT) to the Pelvis +/- Chemotherapy for Post-Operative Patients With Either Endometrial or Cervical Carcinoma
04-17 Clinicaltrials.gov	A Phase II Study of Bevacizumab in Combination with Definitive Radiotherapy and Cisplatin Chemotherapy in Untreated Patients with Locally Advanced Cervical Carcinoma
01-28 Clinicaltrials.gov	A Phase I/II Study Of Cox-2 Inhibitor, Celebrex (Celecoxib), and Chemoradiation in Patients with Locally Advanced Cervical Cancer	PMID 17482376 PMID 17084549 PMID 18299147 PMID 19509178
01-16 Clinicaltrials.gov	A Two-Part Phase I/II Study Of Extended Field External Irradiation And Intracavitary Brachytherapy Combined With Chemotherapy (Weekly Cisplatin-Arm 1) And Amifostine (Weekly Cisplatin And Amifostine-Arm 2) In Carcinoma Of The Cervix With Positive Para-Aortic Or High Common Iliac Lymph Nodes	PMID 17398031
71-05	[Split course vs continuous RT]	PMID 6406397

Review of RTOG Cervix trials:

• RTOG Review; 1999 PMID 11240808 — "Radiation Therapy Oncology Group clinical trials for carcinoma of the cervix." Grigsby PW et al. Int J Gynecol Cancer. 1999 Nov;9(6):439-447.
  • Review of primary data from trials covering hyperbaric oxygen, altered fractionation, hypoxic cell sensitization, chemo-sensitization, prophylactic PA irradiation, and neutrons
  • Positive trials: RTOG 79-20 prophylactic PA RT with IB2 and II disease; RTOG 90-01 concurrent chemo