Radiation Oncology/Radiobiology/Proteins
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Protein Overview
| Protein | Activity | Pathway |
|---|---|---|
| PARP | Single strand damage recognition | BER |
| AP endonuclease | Sugar reside excision | BER |
| DNA glycosylase | Base excision | BER |
| DNA ligase I | DNA ligation | BER Long Patch |
| DNA ligase III | DNA ligation | BER Short Patch |
| DNA polymerase β | Nucleotide repair | BER Short Patch |
| DNA polymerase δ/ε | Nucleotide repair | BER Long Patch |
| Flap endonuclease 1 (FEN1) | Endonuclease | BER Long Patch |
| PCNA | Adapter protein | BER Long Patch |
| XRCC1 | Complex with DNA ligase III | BER Short Patch |
| XPA-XPG | ssDNA repair | NER |
| ERCC6 (CSB) | DNA binding | NER |
| ERCC8 (CSA) | ERCC6 binding | NER |
| Mre11-Rad50-Nbs1 (MRN) | DSB recognition Endo/exonuclease |
DSB recognition HR |
| BRCA1 | MRN regulation | HR |
| Replication protein A (RPA) | scaffold | HR |
| RAD51 | DNA homologue search | HR |
| BRCA2 | RAD51 loading | HR |
| FANC-D | BRCA2 loading S-phase checkpoint |
HR |
| RAD52 | facilitation | HR |
| RAD54 | facilitation | HR |
| TopIIIA | helicase | HR |
| BLM | helicase | HR |
| Ligase I | DNA ligation | HR |
| Ku70/Ku80 | DNA dsb scaffold | NHEJ |
| DNA-PKcs | DNA dsb bridge | NHEJ |
| Artemis | DNA endonuclease | NHEJ |
| Ligase IV | DNA ligation | NHEJ |
| XRCC4 | DNA ligation | NHEJ |
| ATM | dsb response | DNA dsb damage response |
| ATR | ssb response | DNA ssb damage response |
| H2AX | histone | DNA scaffolding |
| p53 | transcription factor | genome control |
| p21 | CDK2/CDK4/cyclin inhibition | cell cycle control |
| cyclinD/CDK4 | G1 phase | cell cycle control |
| cyclinE/CDK2 | S phase | cell cycle control |
| cylinA/CDK2 | S/G2 phase | cell cycle control |
| cyclinB/CDK1 | G2/M phase | cell cycle control |
| Rb | holds E2F in check | cell cycle control |
| E2F | G1 transcription factor | cell cycle control |
| Chk1 | S & G2 checkpoint | cell cycle control |
| Chk2 | S & G2 checkpoint | cell cycle control |
| CDC25A | S & G2 control | cell cycle control |
| CDC25C | S & G2 control | cell cycle control |
| Fas ligand | ligand | apoptosis |
| FAS receptor | receptor | apoptosis |
| FADD | adapter | apoptosis |
| Bid | extrinsic pro-apoptotic | apoptosis |
| caspase 8 | extrinsic pathway initiator | apoptosis |
| Bax/Bak/Bim/Puma | intrinsic pro-apoptotic | apoptosis |
| Bcl-2/Bcl-xL | anti-apoptotic | apoptosis |
| Apaf-1 | apoptosome | apoptosis |
| caspase 9 | intrinsic pathway | apoptosis |
| caspase 3 | apoptosis executor | apoptosis |
| DFF | DNA cleavage | apoptosis |
| IAPs | inhibitors of apoptosis | apoptosis |