Radiation Oncology/Rectum/Review

Rectal Cancer Review

• Surgical margin
  • R0 typically defined as >1 mm
  • Prognostic impact on LR and OS
• Neoadjuvant chemo-RT
  • Superior over adjuvant chemo-RT: German Rectal Trial
  • Superior over neoadjuvant RT alone: EORTC 22921 and FFCD 9203
    • No difference in OS, 5-year ~65%
    • Significant benefit for LR 16-17% -> 8-9%
    • R0 ~90%; ypCR 15-20%