Radiation Oncology/Toxicity/Fertility
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Fertility
- Also please see Toxicity/Ovary
- Also please see Toxicity/Testis
- Also please see Toxicity/Pituitary
- Also please see Toxicity/Pelvis (general information)
- Childhood Cancer Survivor Study (1970-1986)
- 2009 PMID 19364965 -- "Fertility of female survivors of childhood cancer: a report from the childhood cancer survivor study." (Green DM, J Clin Oncol. 2009 Jun 1;27(16):2677-85. Epub 2009 Apr 13.)
- Retrospective. 5,149 femarle CCCS 5-year survivors not surgically sterile and cohort of 1,441 randomly selected female siblings
- Outcome: RR for ever being pregnant 0.81 (SS)
- Negative predictors: hypothalamic/pituitary RT dose >=30 Gy (RR 0.61), ovarian/uterine RT dose >5 Gy (RR 0.56) or RT dose >10 Gy (RR 0.18), treatment with lomustine or cyclophosphamide, or summed alkylating agent dose (AAD) 3-4
- Conclusion: Fertility decreased among female pediatric cancer survivors
- 2009 PMID 19364965 -- "Fertility of female survivors of childhood cancer: a report from the childhood cancer survivor study." (Green DM, J Clin Oncol. 2009 Jun 1;27(16):2677-85. Epub 2009 Apr 13.)